Masafumi Yano Selected Research

Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)

1/2022	Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.
1/2021	Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease.
11/2020	Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling.
1/2020	Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts.
1/2020	Author's reply: The RyR2 - Targeting therapy against lethal arrhythmia.
1/2020	A multicenter, randomized, double-blind, controlled study to evaluate the efficacy and safety of dantrolene on ventricular arrhythmia as well as mortality and morbidity in patients with chronic heart failure (SHO-IN trial): rationale and design.
1/2020	Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice.
1/2019	Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia.
12/2018	Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin.
1/2018	Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.

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Masafumi Yano Research Topics

Disease

41	Heart Failure 01/2020 - 03/2002
18	Cardiac Arrhythmias (Arrythmia) 01/2022 - 09/2005
11	Ventricular Tachycardia 01/2022 - 06/2005
10	Polymorphic catecholergic ventricular tachycardia 01/2019 - 09/2005
9	Atrial Fibrillation 03/2022 - 01/2002
5	Tachycardia (Tachyarrhythmias) 01/2022 - 03/2003
4	Hypertrophy 07/2022 - 12/2006
4	Malignant Hyperthermia 01/2020 - 05/2009
4	Sarcoidosis (Schaumann Disease) 11/2019 - 01/2015
2	Pathologic Constriction (Stenosis) 03/2022 - 06/2017
2	Fibrosis (Cirrhosis) 01/2021 - 03/2008
2	Cardiomegaly (Heart Hypertrophy) 11/2020 - 12/2018
2	Ventricular Fibrillation 01/2020 - 10/2013
2	Myositis (Idiopathic Inflammatory Myopathies) 07/2019 - 01/2018
2	Idiopathic Pulmonary Fibrosis 01/2019 - 01/2016
2	Lupus Nephritis 07/2018 - 01/2017
2	Aortic Valve Insufficiency (Aortic Regurgitation) 01/2018 - 01/2018
2	Cardiomyopathies (Cardiomyopathy) 01/2018 - 06/2006
2	Systolic Heart Failure 01/2014 - 01/2012
2	Cardiotoxicity 10/2013 - 03/2007
2	Heart Diseases (Heart Disease) 03/2008 - 12/2006
2	Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy) 01/2006 - 09/2005
1	Coronary Stenosis (Coronary Artery Stenosis) 03/2022
1	Pulmonary Hypertension 01/2022
1	Atrioventricular Block 12/2021
1	Bundle-Branch Block (Fascicular Block) 12/2021
1	Hypertension (High Blood Pressure) 10/2021
1	Hypertriglyceridemia 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Stroke (Strokes) 01/2021
1	Central Nervous System Vasculitis 01/2021
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2021
1	Non-ST Elevated Myocardial Infarction 01/2021
1	Hemorrhage 01/2021
1	Inflammation (Inflammations) 01/2021
1	Weight Loss (Weight Reduction) 01/2021
1	Pneumonia (Pneumonitis) 01/2021
1	Vasculitis (Vasculitides) 01/2021
1	Fatty Liver 09/2020
1	Cicatrix (Scar) 11/2019
1	Aneurysm (Aneurysms) 11/2019
1	Neoplasms (Cancer) 07/2019

Drug/Important Bio-Agent (IBA)

34	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2022 - 03/2002
9	Calmodulin (Calcium-Dependent Activator Protein)IBA 01/2021 - 04/2010
8	Dantrolene (Dantrium)FDA LinkGeneric 01/2022 - 05/2009
7	Proteins (Proteins, Gene)FDA Link 07/2022 - 03/2005
5	Biomarkers (Surrogate Marker)IBA 03/2022 - 01/2011
5	8-Hydroxy-2'-DeoxyguanosineIBA 12/2017 - 01/2011
4	Epinephrine (Adrenaline)FDA LinkGeneric 01/2020 - 11/2010
3	CatecholaminesIBA 01/2022 - 10/2013
3	Amino Acids FDA Link 01/2020 - 11/2010
3	Milrinone (Primacor)FDA LinkGeneric 01/2019 - 01/2012
3	SteroidsIBA 07/2018 - 06/2016
3	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 06/2006 - 03/2002
3	tacrolimus binding protein 1BIBA 03/2003 - 03/2002
2	Triglycerides (Triacylglycerol)IBA 01/2021 - 01/2015
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 01/2017
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2020 - 01/2016
2	Pharmaceutical PreparationsIBA 01/2020 - 05/2009
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2020 - 01/2018
2	EnzymesIBA 07/2019 - 01/2018
2	landiololIBA 01/2019 - 01/2014
2	Mycophenolic Acid (Cellcept)FDA LinkGeneric 07/2018 - 01/2017
2	AntibodiesIBA 03/2018 - 01/2015
2	Mineralocorticoid Receptor AntagonistsIBA 12/2017 - 02/2005
2	C-Reactive ProteinIBA 01/2015 - 01/2011
2	olmesartanIBA 05/2014 - 10/2011
2	CalciumIBA 12/2012 - 01/2003
2	Carvedilol (Coreg)FDA LinkGeneric 01/2012 - 04/2007
2	Angiotensin Receptors (Angiotensin II Receptor)IBA 10/2011 - 02/2004
2	Protein Phosphatase 1IBA 01/2011 - 06/2006
2	Peptides (Polypeptides)IBA 09/2005 - 06/2005
2	K201 compoundIBA 03/2003 - 01/2003
1	Green Fluorescent ProteinsIBA 07/2022
1	Small Interfering RNA (siRNA)IBA 07/2022
1	UbiquitinIBA 07/2022
1	HomocysteineIBA 07/2022
1	Angiotensin IIIBA 07/2022
1	omega-Chloroacetophenone (Mace)IBA 03/2022
1	MonocrotalineIBA 01/2022
1	lenvatinibIBA 10/2021
1	macitentanIBA 10/2021
1	Sodium-Glucose Transport ProteinsIBA 01/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2021
1	CytokinesIBA 01/2021
1	Ligases (Synthetase)IBA 01/2021
1	MetalsIBA 01/2021
1	TroponinIBA 01/2021
1	Protein Isoforms (Isoforms)IBA 01/2020
1	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2020
1	IsotopesIBA 11/2019
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 11/2019
1	AnticoagulantsIBA 10/2019

Therapy/Procedure

17	Therapeutics 03/2022 - 04/2002
4	Catheter Ablation 01/2022 - 12/2016
4	Transcatheter Aortic Valve Replacement 12/2021 - 02/2016
3	Stents 01/2021 - 04/2016
2	Percutaneous Coronary Intervention 03/2022 - 01/2021
2	Catheters 01/2016 - 11/2015
1	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 11/2020